They have been identified as Caswell Baylis, 45, of Donhead Avenue in St Andrew and 35-year-old Marsha Singh of Honeyhill Close, also in St Andrew.
Reports from the Prospect Police are that about 9:25 pm a Toyota Corolla motor car was travelling towards Ocho Rios when the driver apparently lost control of the vehicle and it crashed into metal barriers on the side of the road.
The occupants of the vehicle received multiple injuries, and had to be cut from the wreckage by firefighters from the Oho Rios Rios Fire Station.
Baylis was pronounced dead at hospital, while the woman was admitted in serious condition and later succumbed to her injuries, the police say.
The Prospect Police are investigating.